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Datos clínicos 2004

• Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer’s disease

  Doody R, Wirth Y, Schmitt F, Möbius HJ (2004). Dement Geriatr Cogn Disord, 18 (2): 227-32.

• Tratamiento con memantina en pacientes con Enfermedad de Alzheimer de intensidad moderada a severa, que ya estaban recibiendo donepezil

  Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I; Memantine Study Group (2004). JAMA, 291 (3): 317-24.

• Hidrocloruro de Memantina

  Witt A, Macdonald N, Kirkpatrick P (2004). Nat Rev Drug Discov, 3 (2): 109-10.

Datos preclínicos 2004

• Effect of memantine on the levels of glial cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated Alzheimer’s disease model

  Ahmed MM, Hoshino H, Chikuma T, Yamada M, Kato T (2004). Neuroscience, 126 (3): 639-49.

• Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis

  Anderson ER, Gendelman HE, Xiong H (2004). J Neurosci, 24 (32): 7194-8.

• Effects of nicotinic and NMDA receptor antagonists on intravenous cocaine and nicotine self-administration in mice

  Blokhina EA, Kashkin VA, Zvartau EE, Danysz W, Bespalov AY (2004). Neuropsychopharmacology, in press.

• Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol

  Culmsee C, Junker V, Kremers W, Thal S, Plesnila N, Krieglstein J (2004). Stroke, 35 (5): 1197-202.

• Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain

  Enz A, Gentsch C (2004). Neuropharmacology, 47 (3): 408-13.

• Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo

  Frankiewicz T, Parsons CG (2004). Neurotox Res, 5 (8): 617-22.

• Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures

  Hare WA, WoldeMussie E, Lai RK, Ton H, Ruiz G, Chun T, Wheeler L (2004). Invest Ophthalmol Vis Sci, 45 (8): 2625-39.

• Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures

  Hare WA, WoldeMussie E, Weinreb RN, Ton H, Ruiz G, Wijono M, Feldmann B, Zangwill L, Wheeler L (2004). Invest Ophthalmol Vis Sci, 45 (8): 2640-51.

• No nerve growth factor response to treatment with memantine in adult rats

  Lang UE, Muhlbacher M, Hesselink MB, Zajaczkowski W, Danysz W, Danker-Hopfe H, Hellweg R (2004). J Neural Transm, 111 (2): 181-90.

• Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

  Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K (2004). FEBS Lett, 566 (1-3): 261-9.

• Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain

  Medvedev IO, Malyshkin AA, Belozertseva IV, Sukhotina IA, Sevostianova NY, Aliev K, Zvartau EE, Parsons CG, Danysz W, Bespalov AY (2004). Neuropharmacology, 47 (2): 175-83.

• Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee (Apis mellifera)

  Si A, Helliwell P, Maleszka R (2004). Pharmacol Biochem Behav, 77 (2): 191-7.

• Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane

  Sukhotina IA, Zvartau EE, Danysz W, Bespalov AY (2004). Behav Pharmacol, 15 (3): 207-14.

• The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats

  Zakharova E, Malyshkin A, Kashkin V, Neznanova O, Sukhotina I, Danysz W, Bespalov A (2004). Behav Pharmacol, 15 (4): 273-8.

• Intraarticular pretreatment with ketamine and memantine could prevent arthritic pain: relevance to the decrease of spinal c-fos expression in rats

  Zhang GH, Min SS, Lee KS, Back SK, Yoon SJ, Yoon YW, Kim YI, Na HS, Hong SK, Han HC (2004). Anesth Analg, 99 (1): 152-8.