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Datos preclínicos 2001

• Neuroprotective and cognition-enhancing properties of MK-801 flexible analogs. Structure-activity relationships

  Bachurin S, Tkachenko S, Baskin I, Lermontova N, Mukhina T, Petrova L, Ustinov A, Proshin A, Grigoriev V, Lukoyanov N, Palyulin V, Zefirov N (2001). Ann N Y Acad Sci, 939: 219-36.

• Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat

  Bienkowski P, Krzascik P, Koros E, Kostowski W, Scinska A, Danysz W (2001). Eur J Pharmacol, 413 (1): 81-9.

• The NMDA antagonist memantine attenuates the expression of opioid physical dependence in humans

  Bisaga A, Comer SD, Ward AS, Popik P, Kleber HD, Fischman MW (2001). Psychopharmacology (Berl), 157 (1): 1-10.

• Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na⁺ currents in rat sensory neurons

  Brau ME, Dreimann M, Olschewski A, Vogel W, Hempelmann G (2001). Anesthesiology, 94 (1): 137-44.

• Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil

  Chizh BA, Reissmuller E, Schlutz H, Scheede M, Haase G, Englberger W (2001). Neuropharmacology, 40 (2): 212-20.

• Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behaviour of MPTP-treated mice

  Fredriksson A, Danysz W, Quack G, Archer T (2001). J Neural Transm, 108 (2): 167-87.

• Alzheimer’s disease: current and future therapeutic perspectives

  Gauthier S (2001). Prog Neuropsychopharmacol Biol Psychiatry, 25 (1): 73-89.

• Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men. a randomized, double-blind, placebo-controlled trial

  Hergovich N, Singer E, Agneter E, Eichler HG, Graselli U, Simhandl C, Jilma B (2001). Neuropsychopharmacology, 24 (5): 590-3.

• The in vivo relevance of the varied channel-blocking properties of uncompetitive NMDA antagonists: tests on spinal neurones

  Jones MW, McClean M, Parsons CG, Headley PM (2001). Neuropharmacology, 41 (1): 50-61.

• In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei

  Kelly JM, Quack G, Miles MM (2001). Antimicrob Agents Chemother, 45 (5): 1360-6.

• Eliciting paresthesias for peripheral nerve block: a harmful clinical standard?

  Kiefer RT (2001). Anesth Analg, 92 (3): 795-6.

• NMDA antagonists inhibit the development of ethanol dependence in rats

  Kotlinska J (2001). Pol J Pharmacol, 53 (1): 47-50.

• Retinal glutamate in diabetes and effect of antioxidants

  Kowluru RA, Engerman RL, Case GL, Kern TS (2001). Neurochem Int, 38 (5): 385-90.

• Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats

  Kozela E, Danysz W, Popik P (2001). Eur J Pharmacol, 423 (1): 17-26.

• Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging

  Le DA, Lipton SA (2001). Drugs Aging, 18 (10): 717-24.

• Increased expression of neuronal Src and tyrosine phosphorylation of NMDA receptors in rat brain after systemic treatment with MK-801

  Linden A, Storvik M, Lakso M, Haapasalo A, Lee D, Witkin JM, Sei Y, Castren E, Wong G (2001). Neuropharmacology, 40 (4): 469-81.

• Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex

  Linden AM, Vasanen J, Storvik M, Lakso M, Korpi ER, Wong G, Castren E (2001). Pharmacol Toxicol, 88 (2): 98-105.

• Memantine, but not dizocilpine, ameliorates cognitive deficits in adult rats withdrawn from chronic ingestion of alcohol

  Lukoyanov NV, Paula-Barbosa MM (2001). Neurosci Lett, 309 (1): 45-8.

• The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain

  Marvanova M, Lakso M, Pirhonen J, Nawa H, Wong G, Castren E (2001). Mol Cell Neurosci, 18 (3): 247-58.

• Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats

  McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA (2001). Gastroenterology, 120 (7): 1737-48.

• Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells

  Oliver D, Ludwig J, Reisinger E, Zoellner W, Ruppersberg JP, Fakler B (2001). Mol Pharmacol, 60 (1): 183-9.

• Memantine treatment in alcohol dementia: rapid PET changes and clinical course

  Preuss UW, Bahlmann M, Bartenstein P, Schutz CG, Soyka M (2001). Eur Neurol, 45 (1): 57-8.

• The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801

  Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgansberger W, Schadrack J (2001). Neuropharmacology, 40 (6): 749-60.

• The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

  Rammes G, Rupprecht R, Ferrari U, Zieglgansberger W, Parsons CG (2001). Neurosci Lett, 306 (1-2): 81-4.

• Effects of pharmacologically induced changes in NMDA-receptor activity on long-term memory in humans

  Rammsayer TH (2001). Learn Mem, 8 (1): 20-5.

• Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats

  Rao VL, Dogan A, Todd KG, Bowen KK, Dempsey RJ (2001). Brain Res, 911 (1): 96-100.

• The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model

  Rimpilainen J, Pokela M, Kiviluoma K, Vainionpaa V, Hirvonen J, Ohtonen P, Jantti V, Anttila V, Heinonen H, Juvonen T (2001). J Thorac Cardiovasc Surg, 121 (5): 957-68; discussion 968-70.

• Glutamate antagonists limit tumor growth

  Rzeski W, Turski L, Ikonomidou C (2001). Proc Natl Acad Sci U S A, 98 (11): 6372-7.

• Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy

  Suzuki R, Matthews EA, Dickenson AH (2001). Pain, 91 (1-2): 101-9.

• Glutamate release promotes growth of malignant gliomas

  Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M (2001). Nat Med, 7 (9): 1010-5.

• The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats

  Talalaenko AN, Gordienko DV, Pankratev DV, Zinkovich II, Krivobok GK (2001). Bull Exp Biol Med, 131 (1): 38-40.

• Competitive and noncompetitive NMDA antagonist effects in rats trained to discriminate lever-press counts

  Willmore CB, Bespalov AY, Beardsley PM (2001). Pharmacol Biochem Behav, 69 (3-4): 493-502.